Clinical Trials & Research

New research in the INFORMS journal Management Science looks at the influence online platforms have on the rising illegal drug epidemic. This study shows drug abuse treatment admissions and overdose deaths have increased since the founding of Craigslist. The paper, “Drug Abuse and the Internet: Evidence from Craigslist,” written by Jiayi Liu and Anandhi Bharadwaj
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The largest-ever clinical trial of a medication for pediatric cardiology patients found that an oral drug significantly improved exercise capacity in adolescent patients with severe, congenital single-ventricle heart defects. A study leader says the physiologic benefits represent a milestone in the care of those who have undergone the Fontan procedure, a palliative operation for single-ventricle
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A Yale-led collaborative study boosts scientific understanding of how the lung disease idiopathic pulmonary fibrosis (IPF) progresses, providing a roadmap for researchers to discover new treatment targets for the disease. The study, led by Naftali Kaminski, M.D., the Boehringer-Ingelheim Endowed Professor of Internal Medicine and chief of the Section of Pulmonary, Critical Care, and Sleep
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Researchers from EPFL and MIT have shown that human mobility is a major factor in the spread of vector-borne diseases such as malaria and dengue even over short intra-city distances. In a paper published in Scientific Reports, the team compares different mobility models and concludes that having access to mobile phone location data can prove
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Research has shown that adults with age-related hearing loss have higher rates of cognitive decline. Now, a study from researchers at Columbia University Vagelos College of Physicians and Surgeons has found that even the earliest stage of hearing loss-when hearing is still considered normal-;is linked to cognitive decline. The study was published online today in
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78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment. Further studies on API-5 expression and inhibition were performed on patient-derived TNBC xenografts, one highly sensitive to chemotherapies and the other resistant to most tested drugs. Clinical analyses of the 78 TNBC biopsies revealed that API-5 was
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With the goal of improving oral health for better overall physical and emotional health, Regenstrief Institute and Indiana University School of Dentistry are joining together to establish a novel dental informatics program. The new program is one of only a few in the U.S., and is perhaps the only dental informatics program in the country
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Toddler speech delays and temper tantrums have long been assumed to go hand in hand, but no large-scale research had successfully backed up that assumption with data. Until now. A new, 2,000-participant study from Northwestern University found that toddlers with fewer spoken words have more frequent and severe temper tantrums than their peers with typical
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New research findings presented at the 2019 ACR/ARP Annual Meeting found a strong association between changes in atmospheric and environmental variables 10 days before a clinic visit and organ-specific lupus flares in patients with systemic lupus erythematosus (Abstract #695). Systemic lupus erythematosus, referred to as SLE or lupus, is a chronic disease that causes systemic
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The protein adipsin, which is produced in body fat, helps protect insulin-secreting cells called pancreatic beta cells from destruction in type 2 diabetes, according to a new study by researchers at Weill Cornell Medicine and NewYork-Presbyterian. Among middle-aged adults, higher levels of the protein in the blood were also associated with protection from type 2
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Nov 8 2019 With World Diabetes Day (14th November) on the horizon new breakthrough research from Monash University has discovered a way to slow the progression of kidney disease in people with diabetes. Led by Associate Professor Melinda Coughlan from the Department of Diabetes, the five-year study initially discovered that a key immune system pathway
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Animal testing will no longer be required to assess a group of deadly neurotoxins, thanks to University of Queensland-led research. Associate Professor Bryan Fry, of UQ’s Venom Evolution Lab, said a new technique could replace conventional methods of testing paralytic neurotoxins, which previously required euthanasia of test subjects. The old method, while extremely efficient, is
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Scientists from 34 countries with an IKBFU researcher among them are working on a medicine for the treatment of ulcerative colitis. IKBFU center for clinical research scientists have participated in the international VARSITY clinical research. It’s the world’s first research aimed at finding the most effective drug among anti-inflammatory ones for the treatment of ulcerative
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A new study published today in the journal Clinical Oral Investigations, has found that sugar-sweetened acidic drinks, such as soft drinks, is the common factor between obesity and tooth wear among adults. Scientists from King’s College London found that being overweight or obese was undoubtedly associated with having tooth wear. Significantly, they also found that
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Researchers from the RIKEN Center for Brain Science in Japan have found certain chemical markers that are associated with schizophrenia. They worked with lab mice with models of schizophrenia as well as post mortem brain specimens of persons with schizophrenia. The study titled, “Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology,” was published
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A new Harvard Medical School analysis shows that papers that present research on health conditions within sub-Saharan African countries in collaboration with wealthy or prestigious institutions or countries often fail to mention local researchers working on the same project, especially in prime positions such as first or senior author. The paper was published on October
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